Background and Aim. Aparallel, randomized, double blinded, placebo-controlled trial study was designed to assess the efficacy of\nsingle low dose of intravenous magnesium sulfate on post-total abdominal hysterectomy (TAH) pain relief under balanced general\nanesthesia. Subject and Methods. Forty women undergoing TAH surgery were assigned to two magnesium sulfate (N = 20) and\nnormal saline (N = 20) groups randomly. The magnesium group received magnesium sulfate 50 mg?kg?1 in 100mL of normal\nsaline solution i.v as single-dose, just 15 minutes before induction of anesthesia whereas patients in control group received 100mL\nof 0.9% sodium chloride solution at the same time.The same balanced general anesthesia was induced for two groups. Pethidine\nconsumption was recorded over 24 hours precisely as postoperative analgesic. Pain score was evaluated with Numeric Rating Scale\n(NRS) at 0, 6, 12, and 24 hours after the surgeries. Results. Postoperative pain score was lower in magnesium group at 6, 12, and 24\nhours after the operations significantly (P < 0.05). Pethidine requirement was significantly lower in magnesium group throughout\n24 hours after the surgeries (P = 0.0001). Conclusion. Single dose of magnesium sulfate during balanced general anesthesia could\nbe considered as effective and safe method to reduce postoperative pain and opioid consumption after TAH.
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